The rapid global movement of people, animals, and goods increases the risks that a local public health crisis could escalate into a worldwide catastrophe. The Stimson Global Health Security Program explores the costs of strengthening health systems in developing nations — and the costs of failing to do so. Our “From the Global to the Local” project engages health leaders in Southeast Asia and sub-Saharan Africa to understand how they define preparedness for outbreaks and emergencies that could spill across borders, and to build a case for partnerships in capacity-building.